Oxford's Paul McLaren is set to return for the clash with Wycombe.
McLaren recovered from a groin injury to feature in the 3-0 win over Burton two weeks ago but was substituted at half-time with a cut just above his Achilles which required seven stitches.
The midfielder's return means boss Chris Wilder has a full squad to choose from, although on-loan Southampton forward Ryan Doble is thought to be in line for a start after coming off the bench to make his debut in last weekend's 3-0 defeat against Bury.
Wilder believes a meeting with local rivals Wycombe is the perfect way to bounce back from that disappointment.
"They'll be up for it," he told Oxford's official website. "They need a win, we need a win. I think it's going to be a great game for my players to show what is needed if we are to be successful next year."
Wycombe boss Gary Waddock has no fresh problems.
Waddock saw his side cement second place with a goalless draw at Hereford in midweek and he could name an unchanged side.
Striker Ben Strevens was back on the bench at Edgar Street after a bout of illness while fellow forward Jon-Paul Pittman was also among the replacements after recovering from a muscle strain in his back.
Veteran defender Chris Westwood has been out with a groin strain but is back in contention and midfielder Matt Bloomfield could miss the next three weeks after he suffered a groin injury which will need surgery.
Left-back Andy Sandell is fit again after a knee problem but midfielder Stuart Lewis has been ruled out for up to three weeks with ankle ligament damage.
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