Tranmere boss Les Parry will assess the fitness of Andy Robinson and Dale Jennings ahead of the home clash with Dagenham.
Midfielder Robinson has missed the last three matches with a groin injury and Parry will assess the former Swansea man's fitness carefully.
Rookie striker Jennings missed last weekend`s 2-1 home win over Bournemouth after he turned an ankle in training and will also be checked.
Defender Mark McChrystal has been nursing a hamstring injury which has affected him for several weeks but Parry said: "It looks like he`s over it now."
Tim Cathalina remains sidelined but Rovers have no other major concerns as they bid to move a step closer to safety.
Parry added: "The aim has always been to get to 50 points as soon as possible and then get as many points as we can after that."
Dagenham are set to be unchanged.
The Daggers were unfortunate to lose 4-3 at Brighton in midweek - a game which saw the Seagulls secure promotion - but a win at Prenton Park would see them continue to climb away from danger and leapfrog Rovers.
Manager John Still has favoured a 4-5-1 shape away from home in recent weeks so striker Jon Nurse will keep his place on the left with John Akinde through the middle.
Akinde has scored in the last two games after finally recovering from a long-term groin injury.
Midfielder Solomon Taiwo is available again following his ankle injury picked up at Swindon a month ago but is likely to be on the bench.
Still's men will be looking to secure just their second win in eight matches to ease their relegation worries.
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