After a week littered with excitement in both the Champions League and the Europa League, it's time to get back down to domestic business.
The Premier League's sixth game week of the season kicks off later tonight as Marcelo Bielsa's Leeds United make the journey to play in-form Aston Villa.
Saturday sees Manchester City travel to West Ham for the 12:30 kick-off, with Manchester United versus Chelsea - the biggest game of the weekend - taking place five hours later.
Virgil van Dijk-less Liverpool face Sheffield United at 20:00 on Saturday, while Arsenal welcome Leicester City to the Emirates at 19:15 on Sunday.
An enthralling weekend of Premier League football signs off with Tottenham's trip to Burnley on the Monday Night Football.
A very exciting set of fixtures and picking a Fantasy Premier League team before the cut off at 18:30 on Friday is not going to be easy.
But we're going to try and do our best to recommend eight players that look set to smash it this game week.
Let's find out who they are...
Sergio Aguero vs West Ham (A) - £10.4m
Aguero's recent injury struggles mean he's currently owned by a tiny fraction of the FPL community.
West Ham's defence was woeful against Spurs and while City are not at their best right now, we fancy Pep Guardiola's side - and Aguero in particular - to score multiple times at the London Stadium.
Ross Barkley vs Leeds (H) - £6.0m
The signing of Barkley on loan has already proven to be a masterstroke by Villa. The Chelsea man was brilliant in the 7-2 mauling of Liverpool and scored a late winner in the recent 1-0 victory away at Leicester.
Barkley has been offered the freedom to attack by Dean Smith and Bielsa's Leeds aren't renowned for defending deep, so expect the Villa man to have plenty of chances.
He appears to have found his shooting boots in the Midlands as well...
Andrew Robertson vs Sheffield United (H) - £7.1m
Trent Alexander-Arnold has endured a bang average start to the 2020/21 season and it's seen much more of Liverpool's play come down the left-side through Robertson as a result.
The Scotsman grabbed an assist against Everton last time out, his second of the season, and we're backing the marauding left-back to take full advantage of an out-of-form Sheffield United.
It's time to save some money by swapping out Alexander-Arnold for Robertson!
Bukayo Saka vs Leicester (H) - £5.3m
If you need a budget-price midfielder, then Arsenal's 18-year-old sensation is the perfect candidate.
Saka was the Gunners' best player in the 1-0 loss away at Man City and this time he's coming up against a Leicester side decimated by injuries - especially in defence.
The England international offers potential for both goals and assists, with the teenager scoring in Arsenal's last Premier League outing at the Emirates against Sheffield United.
Neal Maupay vs West Brom (H) - £6.6m
Maupay has already found the back of the net this season against Manchester United and Chelsea, with four goals to his name overall in 2020/21.
Brighton look a very competent attacking unit and West Brom's defence doesn't exactly represent the most fearsome obstacle for the Seagulls and their French talisman.
If you're in desperate need of making up ground in your league with a unique captain choice, Maupay might be your man...
Marcus Rashford vs Chelsea (H) - £9.5m
After a shaky start to the 2020/21 season, Rashford appears to have rediscovered his mojo and given he's now a midfielder on FPL, you'd be a fool not to bring him in.
The Englishman will carry much of United's attacking burden against a defensively shaky Chelsea as Anthony Martial is still suspended.
Rashford is far from cheap, but well worth the investment, even with United's tough run of league fixtures.
Pedro Neto vs Newcastle (H) - £5.5m
Another cheap midfield option, Neto has started all five of Wolves' Premier League games thus far, scoring the winner against Fulham in GW4.
The Portuguese will almost certainly feature from the get-go at home versus Newcastle and he has the potential to torment a Magpies side reeling from their 4-1 loss to United last Saturday.
Why spend an extra £0.9m on Adama Traore when you can have Neto, eh?
Sergio Reguilon vs Burnley (A) - £5.5m
Don't worry, Spurs' defensive collapse at home to West Ham has been in the back of our minds since last Sunday, but we're still backing Reguilon this week.
The Spaniard assisted Harry Kane's second goal against the Hammers and was a constant attacking threat down the left.
Spurs may not keep a clean sheet against Burnley, but Reguilon will likely make a significant contribution going the other way and for that reason, he gets the seal of approval from us.
- What is the squad value of every Champions League club?
- Ranking the best last-minute goals in Premier League history
- Premier League: The 17 worst collapses in history