Scunthorpe boss Alan Knill looks set to be without winger Jimmy Ryan for the home clash with Preston.
The former Accrington man was forced off with a dead leg after just 19 minutes of the Iron's 2-0 win against Stanley at the Crown Ground in the Carling Cup on Tuesday night.
Knill admits the 23-year-old is struggling to recover in time and Andy Barcham, who replaced Ryan on Tuesday, could now land a starting role.
Striker Jordan Robertson, meanwhile, took a knock in training and will be assessed ahead of the weekend but Matt Godden returned to training on Thursday after overcoming an ankle injury.
Knill has also hinted at a change in tactics, saying: "Preston play a different formation so we might change shape."
Preston manager Phil Brown could hand a debut to new recruit Juvhel Tsoumou.
International clearance for the striker, 20, came through from FIFA on Wednesday afternoon, allowing the deal to be registered.
He signed a two-year contract after a successful trial and will be in the squad at Glanford Park.
Brown has no new injury or suspension concerns and youngster Conor McLaughlin could feature after returning to training following a hamstring injury sustained in pre-season.
Right-back David Gray is still on the comeback trail after suffering a broken leg against Norwich in early March while midfielder Ian Ashbee could again be reduced to the sidelines with a knee problem.
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