Oxford's three long-term absentees will be the only men missing for manager Chris Wilder when Shrewsbury come to the Kassam Stadium.
Experienced defender Tony Capaldi, striker Tom Craddock and midfielder Paul McLaren are yet to appear for the Us this season.
Northern Ireland international Capaldi will be out for a further five weeks with a back injury and will have to wait for his debut.
Craddock, who was the club's joint top-scorer last term, is absent for another three and a half weeks with a knee problem.
McLaren missed a large chunk of pre-season with a knee injury and is not expected to be available any time soon.
The Us and Shrewsbury are both winless so far in the league.
Shrewsbury welcome summer signing Joe Jacobson into their ranks for the first time.
The left-back has been suspended for the club's opening three matches of the season having been sent off in Accrington's play-off semi-final at the end of last season.
And manager Graham Turner could be tempted to throw him straight into the action at the Kassam Stadium having been less than impressed with his side's defending for Burton's opener in Saturday's 1-1 draw.
Turner will also consider starting roles for winger Jon Taylor and striker Terry Gornell after they both came off the bench midway through the second half at the Pirelli Stadium to influence the game, the latter heading a late equaliser for Shrews to snatch a point.
Striker Tom Bradshaw remains in the treatment room after damaging cruciate knee ligaments in pre-season.
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