Crawley welcome defender John Dempster back from suspension for the visit of Southend.
Centre-half Dempster missed Saturday's 2-0 win over Macclesfield through suspension after his opening-day red card at Port Vale.
Charlie Wassmer replaced Dempster at the weekend and could be the man to make way.
Midfielder Dannie Bulman missed out against Macclesfield with an ankle injury and is still unavailable but Ben Smith could return in the centre.
Skipper Pablo Mills remains sidelined with an ankle injury and fellow defender Jamie Day is still out with a back problem.
Scott Shearer is set to get the nod in goal again ahead of Michel Kuipers, who has been struggling with a rib injury.
Mark Phillips will again face a fitness test ahead of the match.
The Shrimpers centre-back failed to shrug off a groin injury in time for Saturday's 2-1 win at Accrington, although fellow central defender Chris Barker handed the Essex-club a huge boost with his inclusion.
Skipper Barker was a shock starter at the Crown Ground having initially been ruled out for the next couple of weeks with a Grade One tear to his groin.
Graham Coughlan, who partnered Barker at the weekend, is again on standby should Phillips not make it, while Paul Sturrock must decide whether central defender Bilel Mohsni is ready for a recall.
Striker Neil Harris and midfielder Jemal Johnson dropped to the bench against Accrington and will be pushing for inclusion from the off.
Barry Corr (knee) and Blair Sturrock (ankle) continue to make progress with their rehabilitation but the encounter comes too soon.
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