Hereford's on-loan midfielder Simon Clist is unavailable to face his parent club when Oxford make the short trip to Edgar Street.
Clist is on loan with the Bulls until January having completed a loan switch from the U's in August but the agreement included a clause which prevents his involvement in this weekend's fixture.
Otherwise, Hereford boss Jamie Pitman will look to keep changes to a minimum having ended a three-match losing streak with last weekend's goalless draw at Cheltenham.
Fit-again skipper Stefan Stam proved his obvious worth as he made his long-awaited return from a hamstring injury with a commanding defensive performance at Whaddon Road.
Pitman opted for experience as he also brought back Kenny Lunt and Delroy Facey, dropping Will Evans, Harry Pell and Yoann Arquin.
Striker Sam Winnall has extended his loan stay from Wolves into a second month and is again likely to start, but midfielder Joe Colbeck (knee), goalkeeper Adam Bartlett (thigh) and defender Benoit Dalibard (hamstring) continue to miss out.
Jake Wright will return to the Oxford starting-line up.
The club captain has served his one-match suspension after being shown two yellow cards at Barnet, and is likely to replace Andy Whing in defence.
That could be the only change, with manager Chris Wilder expected to name the same XI that has given him two consecutive away wins.
Tony Capaldi (back), Tom Craddock (knee) and Anthony Tonkin (hamstring) remain sidelined for the Us.
Wilder will be hoping his players can keep Hereford in the League Two relegation places by condemning them to a fourth defeat in five matches.
A win would also see Oxford reclaim their place in the play-offs, having dropped out of the top seven following a 1-1 draw with Accrington.
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