Oxford manager Chris Wilder is likely to revert back to the side which beat Hereford 1-0 in League Two last weekend for the meeting with Bristol Rovers.
Wilder made five changes to his team for the midweek 2-1 victory over Aldershot in the Johnstone's Paint Trophy, but the Oxford boss is set to draft back in regular first-teamers Michael Duberry, James Constable, Alfie Potter and Paul McLaren for the visit of Rovers.
Deane Smalley is pushing for a second successive start after netting his first goal for the club on Tuesday night, although it is expected that Constable will partner Rob Hall up front. Hall's loan stay from West Ham was extended a further month on Wednesday.
Meanwhile, defenders Anthony Tonkin (hamstring) and Tony Capaldi (back) and striker Tom Craddock (knee) all remain sidelined as Oxford look to extend their unbeaten league run to six matches.
Bristol Rovers' injury curse has struck once again ahead of the clash.
Danny Woodards, Wayne Brown, Matt Gill and Scott McGleish are all in the treatment room as Rovers prepare to make the trip to the Kassam Stadium.
Defender Woodards was stretchered off with a rib injury during last weekend's defeat to Cheltenham, while midfielder Brown damaged his ankle in the same game.
To make matters worse for manager Paul Buckle, it appears Brown will be sidelined for some considerable length of time.
Striker McGleish is also a major doubt for the game against the Us and club captain Gill is struggling with a hamstring problem which has dogged his season to date.
"Scott was a real worry last week, and we are still going to get him scanned," Buckle told the club's official website.
"Brown is fairly long-term. He has hurt his ankle quite badly. When you lose a couple it makes it disjointed and difficult, but we remain positive."
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