The two battled for 12 rounds and the Ukrainian came out on top with scores of 117-112, 116-112, and 115-113.
He thus handed Joshua the second defeat of his career while maintaining his perfect record, winning 19 out of 19.
Both fighters also earned large sums from the event with Total Sportal claiming that Joshua will pocket £10 million along with a share of the PPV sales which takes his purse to around £15 million.
Usyk is guaranteed to earn £3 million for the fight and could be paid another £1-2 million if PPV targets are met. This is his career-best purse till date.
The Ukrainian was dominant throughout and even admitted that he had to be talked out of knocking Joshua out.
After the fight, the Ukrainian said: "This means a lot to me. The fight went exactly the way I expected it to go.
There was times when Anthony pushed me hard but nothing special. I had no objective to knock him out. My corner pushed me not to do that.
"My trainer said no and to stick to my job. I've been working so hard since January. It took me some half a year. I miss my children. I want to go home.
"I'm not thinking about the rematch. You didn't see the best Usyk. I can be much better."
After seeing the Ukrainian's performance, it won't be unfair to call him the best heavyweight boxer in the world.
A rematch between Usyk and Joshua is on the cards and if that takes place, there's a good chance of the former's purse being higher.
A fight between Joshua and Fury seems farfetched now and there's probably more chance of the latter fighting Usyk for the heavyweight titles.
It won't be surprising if The Gypsy King calls out The Cat after his fight against Deontay Wilder.News Now - Sport News