Norwich v Arsenal
Arsenal kick off this weekend's Barclays Premier League action, travelling to Carrow Road to face Norwich as the look to maintain the resurgent form.
Robin van Persie will want to maintain his phenomenal scoring record, with 29 goals in 28 league games in 2011, while Laurent Koscielny returns for the Gunners.
Manchester City v Newcastle
The only two unbeaten sides so far this season meet at the Etihad Stadium, when something will surely give, with Roberto Mancini's men top and in sensational form.
Owen Hargreaves and Samir Nasri are likely to miss out, but Sergio Aguero has been declared fit to face Alan Pardew's side, who will provide a stern test.
Swansea v Manchester United
Reigning champions Manchester United will be looking victory to keep pace with their rivals - but face a Swansea side unbeaten at home.
Ashley Young and Tom Cleverly could return just in time for Sir Alex Ferguson, but injuries to other key players mean Wayne Rooney may once again start in midfield.
Everton v Wolves
Everton take on Wolverhampton, with the home side boosted by the news influential midfielder Marouane Fellaini has signed a new long term contract.
Sunderland v Fulham
Sunderland are also in action against Fulham, with both sides desperate to achieve some sort of consistency in a tough season so far.
Wigan v Blackburn
Wigan take on Blackburn in a what is already being billed as a relegation scrap. With both rock bottom, 3 points could be a monumental boost for the victors.
West Brom v Bolton, Stoke v QPR
Elsewhere on Saturday, West Brom welcome Fulham to the Hawthorns, while QPR face a tough trip to Stoke City, who are looking to bounce back from a poor run.
Chelsea v Liverpool
Sunday sees a huge clash between Chelsea and Liverpool at Stamford Bridge, with both teams desperate to avoid dropping points and falling behind leaders City.
Fernando Torres will be the centre of attention if he starts for the home side, but he faces competition from fit again Didier Drogba and Daniel Sturridge.
Liverpool meanwhile should have Jamie Carragher and Luis Suarez available for selection are shaking off knocks, but captain Steven Gerrard remains injured.
Tottenham v Aston Villa
On Monday, Tottenham manager Harry Redknapp will be hoping for a stress free victory when he takes his place in the dugout after recovering from heart surgery.
Tottenham are on a three match winning streak in the league, with an unbeaten run stretching to August. Jermaine Defoe could start, with Rafael van der Vaart a doubt.