Manchester United v Newcastle - Old Trafford, 15:00
Manchester United take on Newcastle United on Saturday, with history suggesting the once bitter title rivals will produce another thrilling match at Old Trafford.
Wayne Rooney and Danny Welbeck expected to return to the starting line up for United after missing out on the midweek Champions League with Benfica.
Chelsea v Wolverhampton - Stamford Bridge 15:00
Nothing but 3 points will be enough for Andre Villas-Boas, who finds himself under pressure after a disappointing run of results has left his side 12 points of the pace.
Fernando Torres will likely return to the starting line up in place of Didier Drogba, will Oriol Romeu could make his first league start, shielding the back four.
Arsenal v Fulham - Emirate Stadium 17:45
Arsenal will be confident of maintaining their sensational form when they welcome Fulham to the Emirates Stadium in the late kick-off on Saturday afternoon.
Arsene Wenger is almost certain to stick with the same side that beat Borussia Dortmund in midweek with an impressively resilient performance.
West Brom v Tottenham - The Hawthorns, 15:00
Harry Redknapp's side could make it 5 straight league wins with victory over West Brom on Saturday, as they aim to strengthen their grip on third place.
Roy Hodgson's side will provide a stern test after a morale boosting victory last week, but in form Gareth Bale will be looking to inspire Spurs to another 3 points.
Bolton v Everton
Bolton have lost seven out of their last eight home games, but will be looking to climb out of the relegation zone with victory against Everton on Saturday.
Sunderland v Wigan - Stadium of Light, 15:00
Wigan visit Sunderland with Roberto Martinez's side desperate for 3 points with games against Arsenal, Chelsea and Liverpool before Christmas.
Stoke v Blackburn - Britannia Stadium, 12:45
Norwich v QPR - Carrow Road, 15:00
Elsewhere in the Barclays Premier League on Saturday, Stoke City take on struggling Blackburn Rovers while Norwich welcome Queens Park Rangers.
Liverpool v Manchester City - Anfield, 16:00
The biggest clash of the weekend sees Liverpool take on a Manchester City side who have dropped just two points in the the Barclays Premier League this season.
Roberto Mancini's side will be desperate to bounce back from midweek disappointment in the Champions League by, with Sergio Aguero expected to start.
Steven Gerrard remains on the sidelines, meaning Kenny Dalglish is likely to field the same side that beat Chelsea - though Stewart Downing will be pushing to start.
Swansea v Aston Villa - Liberty Stadium, 13:30
Finally on Sunday, Swansea welcome Aston Villa to the Liberty Stadium, with the away side incredibly looking for the just their first away victory of the season.