Arsenal manager Arsene Wenger is set to rest several key players for tonight's Carling Cup quarter-final clash with Manchester City.
Alex Oxlade-Chamberlain and Park Ju-Young are just two of the players set to be handed rare starting opportunities this evening.
Roberto Mancini will also make wholesale changes, with midfielder Owen Hargreaves set to make his second appearance for the club.
Meanwhile, Andre Villas-Boas will be without suspended captain John Terry as Chelsea welcome Liverpool to Stamford Bridge.
The Chelsea manager is likely to give Romelu Lukaku a chance to impress up front as the Blues aim for quarter-final victory.
Andy Carroll is set to lead the line for Kenny Dalglish's side, while Sebastian Coates will make his first start since joining the club.
Today's transfer news sees reports that Didier Drogba is ready to leave Chelsea, having rejected a new contract offer.
Arsenal are scouting Cologne and Germany striker Lukas Podolski with a view to bid in the January transfer window.
Tottenham Hotspur are said to be closing in on the signing of versatile Ajax defender Jan Vertonghen.
Liverpool could make a surprise move for Real Madrid striker Royston Drenthe - currently on loan at Everton.
Manchester United manager Sir Alex Ferguson is said to be tracking £13m Swedish international midfielder Rasmus Elm.
And finally, Manchester City are facing competition from PSG for the signing of Napoli forward Edinson Cavani.