Arsenal are set to face Barclays Premier League leaders Manchester City in 10 days' time without any recognised full-backs reports the Daily Mail.
With long-term absentees Bacary Sagna, Carl Jenkinson, and Kieran Gibbs on the treatment table, the Gunners received a further blow when Andre Santos injured his left ankle in Tuesday's 3-1 UEFA Champions League defeat to Olympiacos.
That means Thomas Vermaelen will be shifted over to the left side of defence, leaving Per Mertesacker and Laurent Koscielny in the middle, and fellow centre-half Johan Djourou being forced to continue his stint in an unfamiliar right-back role.
Arsene Wenger may need to promote 17-year-old Swiss defender Martin Angha to the first-team to face Everton on Saturday - a player who is yet to receive a senior cap for Arsenal.
Angha was set to feature in Greece this week, but was sent home by Gunners assistant manager Pat Rice after it became apparent he would be ineligible to play because the defender was not named in the club's UEFA Champions League squad.
The injury crisis threatens to wreck an excellent run of form for Arsenal, with the side unbeaten in their last seven Barclays Premier League outings, Wenger will be hoping to keep momentum as they look to continue pushing up the table.