Wigan v Chelsea
Chelsea are in Barclays Premier League action on Saturday, travelling to the DW Stadium to take on a Wigan side who are starting to get results.
Andre Villas-Boas will be confident of victory nonetheless, with the in form Didier Drogba set to lead the line and a returning David Luiz likely to start.
Newcastle v Swansea
Newcastle welcome Swansea to St James Park, in a battle between two of the finest goalkeepers in the league - Dutchmen Tim Krul and Michel Vorm.
Fulham v Bolton
Bolton travel to Craven Cottage with Owen Coyle desperate for three points with his side rock bottom of the league in an increasingly alarming position.
Everton v Norwich
David Moyes will be hoping his side can end their goal drought - having not scored in 192 minutes of play - to move level with Norwich in the table.
Blackburn v West Brom | Wolves v Stoke
Elsewhere on Saturday, struggling Blackburn are looking for just their third win, while precariously positioned Wolves need three points against Stoke.
Manchester City v Arsenal
On Sunday, Manchester City and Arsenal face at the Etihad Stadium in what promises to be yet another Barclays Premier League encounter.
Roberto Mancini's side are aiming to bounce back from their first league defeat to Chelsea, but will be without suspended former Gunner Gael Clichy.
Arsenal will be facing the sternest test of their sensational unbeaten run - compounded by the face Arsene Wenger is facing a defensive injury crisis.
Aston Villa v Liverpool
Stewart Downing returns to Villa Park for the first time since his summer move to Anfield, but striker Luis Suarez starts his lengthly FA ban.
QPR v Manchester United
In Sunday's early kick off, Sir Alex Ferguson may be forced to field young midfielder Paul Pogba, with injuries decimating his midfield options.
Tottenham v Sunderland
Finally on Sunday, Tottenham face Sunderland and new manager Martin O'Neill determined to return to winning ways following a bitter defeat at Stoke.