Ali Al-Habsi saved a Charlie Adam penalty and made a string of other fine saves to help Wigan hold Liverpool to a point at the DW Stadium.
Reds boss Kenny Dalglish will rue a number of missed chances as the visitors dominated the opening stages of the game.
The much-maligned Luis Suarez was a constant menace to the Latics' defence, and it was the Uruguayan who won the second-half penalty after his acrobatic bicycle kick was handled by defender Gary Caldwell.
Dirk Kuyt was guilty of missing Liverpool's next best chance of the game following Adam's spot-kick miss, but the Dutchman fired over from just six yards out.
As the game wore on, Wigan started to get a foothold in what was a pulsating game, with goalmouth action at either end - the goalless scoreline seemingly not doing the entertainment justice.
Roberto Martinez threw on Colombian striker Hugo Rodallega in the closing stages, and it almost proved to be pivotal, but his close-range header was deflected wide by Glen Johnson.
The result leaves Wigan in the bottom-three, just one point from safety, while Liverpool remain sixth but lose ground on Arsenal who won 2-1 at Aston Villa.
The Reds have now failed to win away at Wigan in their last four attempts, but a draw maintains their impressive record on their travels this season.