Spurs welcome the Toffees to White Hart Lane this evening as they look to extend their run of just one defeat in their last 17 league fixtures.
Tottenham's two previous home encounters have ended in hard-fought 1-0 victories against Sunderland and West Brom, and Defoe is anticipating another tough test when David Moyes' side arrive in north London.
"It all stems from the manager, he gets them working hard," said Defoe, who hit the winner against West Brom in Spurs' last Barclays Premier League outing.
"That's the first thing you bring to the game and if your work-rate is good, the rest of it takes care of itself, the football side of it."
Defoe has enjoyed a run in Harry Redknapp's starting line-up in recent weeks, and is hoping to cement his place in the side by maintaining his goalscoring form.
"It's always tough against Everton," he added. "But we're full of confidence and we have to try and keep doing what we're doing.
"We're at home, we're playing well and we have to be ruthless."