Franco Di Santo's classy strike put Wigan on course for a 2-0 victory at Southampton as the newly-promoted side paid for their inability to find a way past Ali Al-Habsi.
The Argentinian striker's second-half goal was followed up late on by an Arouna Kone effort as the Latics racked up their first points of the season at St Mary's.
Southampton started their first home Premier League match in seven years strongly and captain Adam Lallana saw an early long-range effort tipped onto the bar by Athletic goalkeeper Al-Habsi.
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