Wales fell to their third defeat in four World Cup qualifiers after being overrun 2-0 by a dominant Croatia side in Osijek.
The Dragons did well to keep their hosts at bay until the 27th minute, when goalkeeper Lewis Price tried to clear a weak Ashley Williams back-pass but the ball was charged down by Mario Mandzukic, who tapped home.
Former Arsenal forward Eduardo then made it 2-0 after the break with a close-range finish.
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