With the Premier League title now gone, Manchester City’s early clash with West Ham United takes on much less significance.
Roberto Mancini’s side will be eager to secure second place however, whilst the Hammers are ready to think about their summer holiday in mid-table.
Wigan’s clash against Tottenham is the pick of the three o’clock kick-offs, with huge connotations at both the top and bottom of the table.
Spurs need a win to keep pace with the top four, whilst Wigan are desperate for three points in their battle for Premier League survival.
Everton host Fulham in their continuing fight for a European place, whilst Stoke meet Norwich both need another win to make sure of their own survival.
Southampton have surprised many this season, and their reward for being safe in mid-table is a meaningless clash against West Brom.
On Sunday, Reading and QPR meet in a match that is almost certainly going to take place in the Championship next season, before Chelsea host Swansea looking to secure their spot in the Champions League places.
Arsenal then host Manchester United in a super Sunday clash, with Sir Alex Ferguson’s side expected to receive a guard of honour at the Emirates Stadium.
Robin Van Persie makes his return to north London to face the Gunners, and will expect a hostile reception as Arsene Wenger’s side battle for a top four finish.
Finally, to conclude the weekend action, Aston Villa meet Sunderland on Monday night, with Paolo Di Canio looking to make it three-from-three since taking charge at the Stadium of Light.
A win for the Villains would bring the Black Cats right back into the relegation mix, however, whilst giving their own survival chances a boost in the process.
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