Wigan Athletic manager Roberto Martinez fears that defender Ronnie Stam has suffered a broken leg during the side's 3-2 home defeat to Swansea City on Tuesday night.
Stam came on in the second-half for the relegation-threatened side but could only play for less than a minute before going down under a heavy challenge and being forced off the pitch.
Wigan went into the game knowing that they had to win to face a chance of surviving in the Premier League yet again and at half-time things were looking good for the Latics after a Roger Espinoza goal gave them the lead just before the break.
However the second-half started horribly for Martinez's men as Angel Rangel equalised with a sweet volley, but soon after that James McCarthy restored Wigan's lead.
At this point the result was enough to see Wigan jump above Newcastle United and Norwich City, but things only went downhill from then on.
A Itay Shechter and a Dwight Tiendalli goal was enough for the Swans to secure three points and push Wigan into even deeper trouble.
The result was made worse by Martinez confirming that defender Stam could have suffered a broken leg and will miss the FA Cup final and the remaining two games of the season.
Martinez told reporters: "We will check Ronnie tomorrow, but it seems it is a broken leg.
"He couldn't put any weight on it, so he will need a scan tomorrow to find out exactly what it is."
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