Injuries to key players
Admittedly this is a problem that can beset any side in the professional game, but Arsenal seem to be more prone to it than most.
Figures such as Mikel Arteta, Jack Wilshere and Aaron Ramsey will often pick up knocks that rule them out of games here and there and, whilst they're usually able to cope with the absences, Arsenal will need their very best players for the majority of the time if they're going to win the game.
It's unfortunate that a number of their star players seem to more susceptible to injuries but it is a very realistic problem nonetheless.
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