Arsenal welcome Napoli to the Emirates Stadium as they look to increase their foothold in their Champions League group.
But the Gunners don't have it at all easy, it will be a hard game for the London side.
Napoli sit second in their league, boasting players such as Marek Hamsik, Gonzalo Higuain, Lorenzo Insigne and Jose Callejon. Looking at Arsenal's lengthy injury list, could it be a walk over for the Italian side?
Arsenal currently remain without Theo Walcott, Santi Cazorla, Yaya Sanogo, Lukas Podolski, Alex Oxlade-Chamberlain and Abou Diaby.
But the Gunners have been good this season, even without their star six, it is going to take a lot to beat them. They managed a 3-1 win over Swansea on Saturday.
Napoli also earned a 2-0 victory over fellow side Genoa ensured they stayed without a loss. Arsenal's only loss came on the opening day of the season against Aston Villa, yet they haven't let in many goals since then.
Higuain will line up against the side who tried to steal him in the summer. Wenger has highlighted his ex-target as a real threat to his side.
It is not the best moment to talk about transfers," Wenger said. "He was on the market, as you know, and several clubs were in for him.
"I do not think it needs to be talked about again."
He added: "We have to be organised against Napoli because they are very good on the counter-attack.
It is anyone's game and definitely to close to call! But what are the predicted line-ups? Check them out below.
Arsenal: Szczesny; Sagna, Mertesacker, Koscielny, Gibbs; Flamini, Ramsey; Gnabry, Ozil, Wilshere; Giroud
Napoli: Reina; Mesto, Albiol, Britos, Zuniga; Dzemalli, Inler; Callejon, Hamsik, Pandev; Higuain
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