The midfield pair played alongside each other in the 2007/2008 season as Arsenal were favourites for the title before their February breakdown.
The Gunners topped the table going into February and were delighting fans with their fantastic football.
Crucial to the side's success was their midfield quartet, with Cesc Fabregas and Alex Hleb operating alongside the current Arsenal duo.
However, their title charge fell away soon after Eduardo broke his leg in a dramatic game at St Andrews against Birmingham.
Rosicky, meanwhile, must have dreamt of numerous 'what ifs' while he lay crocked on the treatment table.
And it is this disappointment - likely still fresh in the midfielders' minds - that can spur Arsenal on to the title.
The last time Arsene Wenger's side lifted the Premier League, was off the back of a late season blip the season before.
In 2002/03 the title looked to be heading to Highbury but for Manchester United to snatch the crown late on.
Thierry Henry and co. used this as motivation, and Flamini and Rosicky can do the same.
Another member of the current squad who played in the 07/08 side was Bacary Sagna, and the right-back's similar memories could be equally important for the Gunners.
He had just joined from Auxerre that summer and established himself as Arsenal's first choice right-back.
A win at Old Trafford would go further still in quieting their critics.
And though the headlines may be being stolen by the present form of Ramey, Ozil and Giroud, it could be the past regrets of Flamini and Rosicky that bring the title to the Emirates.
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