Ashley Young and Anderson will be the first out the exit door as David Moyes prepares a clear out at Manchester United, reports the Daily Mirror.
The midfield pair have become surplus to requirements at Old Trafford with neither featuring heavily for the Premier League champions this season.
Moyes will be looking to offload the pair on permanent deals but is so desperate to see them gone, is willing to agree a loan deal if a buyer can not be found in January.
Anderson, who joined for £24m from Porto in 2007, has been unable to live to the heavy price tag, leaving Moyes unconvinced that he can rely on the star as he continues to rebuild the team he inherited at Old Trafford.
Similarly, Young, who joined from Aston Villa for £17m in 2011, has regressed in to obscurity following a good start to his Manchester United career.
He now finds himself behind 18-year-old Adnan Januzaj in the pecking order and hasn't started a game since the 4-1 defeat to Manchester City.
Selling the pair on a permanent basis will open open funds for Moyes to move for Everton left-back Leighton Baines.
If he does manage to land the England defender, it is reported that Alex Buttner will follow Anderson and Young out the door.
Moyes is also targeting a big money move for Ilkay Gundogun as a replacement for Anderson.
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