Liverpool boss Brendan Rodgers has confirmed that he will be without defensive trio Daniel Agger, Glenn Johnson and Mamadou Sakho for his team's tie against Arsenal this weekend.
The two Premier League big guns go head to head at Anfield on Sunday.
Arsenal have plenty of their own injury worries, with Aaron Ramsey and Theo Walcott both out of the game, while Mikel Arteta and Jack Wilshere are in a race against time to be fit.
However Liverpool look to be worse off going into the game after Rodgers confirmed that he'll be without three key players at the back for the crunch clash against the Gunners.
When asked if Agger, Sakho or Johnson would be fit to face Arsenal, Rodgers said: No, they'll not be back for this one, but we're hopeful that next week [they will be back]," the Reds boss told reporters when asked about Johnson and Agger.
"Glen Johnson is making a great recovery, so there might be a point towards the middle or end of next week [when he can return]. Daniel Agger will hopefully be next week at some stage.
"Sakho is still out for a little bit, but apart from that we will be the same as what we have been for the weekend."
Liverpool will look to dent Arsenal's title hopes when they travel to Anfield, while maintaining the gap to those behind them in the race for a top four finish.
The Reds have dropped just two points at home all season, and Rodgers says he is confident that his side can stop the Premier League leaders.
Sometimes I feel, the bigger the game, the better we've played," he explained. "At the Emirates though, Arsenal were the better team.
"Every game is critical now before the end of the season. Every team will look to take points off their rivals.
"If we win this weekend, we close the gap on the teams above us. So we need to make sure the performance is right.
"These types of games are an opportunity to make a statement of the progress we've made.
"When I came in, there wasn't much confidence to consistently win. Now there is and none more so than at Anfield.
"We'll respect our opponents, and none more so than Arsenal, but we'll expect to win and have the confidence to do so."