Both teams enjoyed wins at the weekend but Manchester United are obvious underdogs, especially as this season Old Trafford has looked nothing like the fortress that Sir Alex Ferguson left.
But the last week has renewed a bit of hope for the United faithful, overturning a 2-0 deficit to Olympiakos midweek to progress to the quarter final of the champion's league, and then comfortably navigating a tricky away fixture against West Ham.
City also come off a weekend win having thrashed lowly Fulham 5-0, including a stunning hat-trick from Yaya Touré.
For Moyes' men to beat their neighbours they must do three things:
Select wingers that will provide width
Moyes experimented with playing Adnan Januzaj and Juan Mata on the wings in an effort to play all the best players he has at his exposal, but the truth is United are nowhere near fluid enough to make the most out of these players and their constant insistence on coming inside did nothing to stretch the game to give the middle men room to play
The best options would be Danny Welbeck and Antonio Valencia. Both will track back to cover Patrice Evra and Rafael (who let's be honest, need to be given cover) along with having the pace and directness to go wide to receive the ball - giving United more options in the middle when on the ball and also presenting a huge counter attack threat.
Play Juan Mata in his best position
Now Robin van Persie is injured again, Moyes doesn't have the option to fit him, Rooney and Mata in the same team, leaving space for Rooney to play up front and Mata to play behind him.
In that position Mata became one of the best playmakers in the world - and was Chelsea's Player of the Season because of it. Playing him there and allowing him to get on the ball and open up space beautifully - and he'll always provide world-class service to a very confident Rooney.
Mark Yaya Touré out of the game
Few would disagree that Touré is the most influential player in the current Manchester City side, effecting the game hugely from both a defensive and offensive perspective. When Chelsea beat City 1-0 one of the biggest factors was Nemanja Matic.
Matic terrorised Toure that day, not giving him time to settle on the ball all game and imposing himself physically in a way we rarely see against the powerhouse Ivorian. This will be Marouane Fellaini's job. No doubt he has the size and strength to do so, and will probably best Touré in the air in most occasions. The real test will be if he can do so for 90 minutes, if he can, don't be too surprised to see all three points going to the red side of Manchester.
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