With six of the top eight seeds gracing Court Central, there are some intriguing battles set to take place on day six of the Monte Carlo Masters.
The action will get under way with Australian Open champion Stanislas Wawrinka taking on big serving Canadian Milos Raonic, in what will be the first meeting between the two players on clay.
Wawrinka, seeded three, has won his previous two meetings against his eighth-seeded opponent, and he looked in strong form when defeating Marin Cilic 6-0, 6-2 in the second round, before being given a walkover past the injured Nicolas Almagro.
Raonic comfortably beat 11th seed Tommy Robredo 6-4, 6-3 to make it into the last eight on Thursday, and both players are aiming to win their first Masters Series title.
That match will be followed by an all-Spanish affair between world number one Rafael Nadal and sixth seed David Ferrer.
The pair will be playing in a repeat of last year’s French Open final, and both have been on deadly form in the tournament so far.
Nadal, an eight-time champion at this event, has been untroubled in two straight set victories over Teymuraz Gabashvili and Andreas Seppi, while Ferrer dropped just three games against Jeremy Chardy in the second round, before dispatching the Bulgarian Grigor Dimitrov 6-4,6-2.
It will be their first match against each other in 2014, and Nadal holds a formidable record against his compatriot, winning 21 out of 26 of their previous encounters, including the 2013 final at Roland Garros and the 2011 final in Monte Carlo.
Then it’s over to a mouth-watering contest between home favourite Jo-Wilfried Tsonga and Roger Federer.
The Frenchman dominated the 17-time Grand Slam winner Federer when they met in the quarter-finals at the French Open last year in three sets, and he also holds the title of being the first man to beat Federer having been two sets down, which happened in the quarter-finals at Wimbledon in 2011.
But the Swiss, who entered the tournament via a wildcard, has looked in ominous form on his way to the last eight, dropping just eight games in four sets against Radek Stepanek and Lukas Rosol.
Tsonga has had more time on court, as he came back from a set down to beat Italian Fabio Fognini 5-7, 6-3, 6-0 on Thursday, and he will aim to overcome the man who has been runner-up three times in Monte Carlo.
Reigning champion Novak Djokovic will then end proceedings in the singles for the day against Spaniard Guillermo Garcia-Lopez, as he continues his quest to win a third consecutive Masters Series title.
The Serbian was at his best against clay-court specialist Pablo Carreno Busta, as he took just 47 minutes to win 6-0, 6-1 and complete his 12th victory in a row.
But he will have to have his wits about him against Garcia-Lopez, who defeated fifth seed Thomas Berdych in the third round and has won two singles titles on clay previously.
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