Atletico Madrid trio Diego Godin, Cristian Rodriguez and Jose Giminez have been named in Uruguay’s provisional World Cup squad.
Espanyol forward Christian Stuani has also been included in Oscar Tabarez’s 25-man party.
The final selection will see the list reduced to 23 and must be submitted to FIFA by June 2.
Godin has been a regular presence at the heart of Atletico’s defence in their pursuit of league and European glory this season, making 33 appearances in La Liga and scoring three goals.
Having made his debut in 2005, he also appeared at the 2010 finals which saw Uruguay reach the last four.
Rodriguez has featured predominantly as a substitute for Diego Simeone’s side, with 18 in the league and another nine in Los Rojiblancos’ run to the UEFA Champions League final.
His experience of 71 caps for his country has given him the edge over alternative options. This will be his first finals should he remain in the 23, after he was overlooked last time around following his suspension for an assault on Argentina’s Gabriel Heinze during the qualifying stages.
Like Godin, he was a member of the side that won the 2011 Copa America.
Giminez, 19, has only played twice this season, but his performances for Uruguay at the U20 World Cup last year seem to have stood out in the mind of Tabarez.
Stuani completes the La Liga quartet. He has scored six times in 33 games and provides a further attacking option to accompany the likes of Luis Suarez, Edinson Cavani and former Atletico and Villarreal striker Diego Forlan.
This is joint-second best representation of Spanish-based players for the finals along with the squad of 2010 that enjoyed a very successful tournament and reached the semi-finals in South Africa.
The highest ever amount of La Liga players in a Uruguay World Cup squad was five in 2002, when they went out at the group stages.
Uruguay were drawn into a tricky Group D alongside Italy, England and Costa Rica.
Their competition gets underway against Costa Rica on June 14, before facing the English five days later.
Cesare Prandelli’s Italian side will be the opposition in their final group match on June 24.
Should they get out of the group, the two-time winners will more than likely face a slightly easier second-round clash. With Colombia, Ivory Coast, Japan or Greece set to be the opponents, a potential meeting with hosts Brazil or holders Spain awaits in the quarter-finals.
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