Matthews was having a successful Giro after wearing the pink jersey from stage three until the end of stage eight as well as holding the Best Young Rider and King of the Mountains jersey's for multiple stages.
His Orica-GreenEDGE team won the team time trial on the first stage of the race and Matthews added a second stage win when he sprinted to victory on stage six.
Unfortunately though after falling of his bike on Sunday and suffering from a thigh injury on his right leg the Australian had to abandon the race just before stage 11 today.
Matthews did ride in the stage yesterday and finished in an impressive third place behind Nacer Bouhanni and Giacomo Nizzolo but it was clear he was in some pain.
Orica-GreenEDGE said, according to Sport24: "Michael fought to get a result despite the pain. What's certain is he's learnt a lot from this Giro."
It has not been said how serious the injury is but Matthews and Orica-GreenEDGE will hope he will be back for the Tour de France.
The Australian leaves the race in the hands of Cadel Evans who currently leads the race and is favourite to win it when it finishes on 1st June.
Matthews has had a fairly successful year so far with success in two stages of the Giro as well as winning the Vuelta a La Rioja. He also won stage 3 of the Tour of the Basque Country.
The 23 year-old would have gained valuable experience from his week at the Giro and there is plenty of things he can take from his time in Ireland and Italy. There is no shame in losing the maglia rosa to a rider such as Evans.
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