Newcastle's winless run was extended to 20 matches as the Falcons fell to a 35-18 defeat away at Wasps on Sunday.
Wasps wing Tom Varndell bagged two tries and James Gaskell and Rob Miller also touched down to inflict more misery on a Newcastle side that hasn't tasted victory since they beat London Irish in October 2013.
Only two sides have gone longer without a win in the competitions 27-year history - Rotherham and Worcester - and the Falcons will be hoping for a reverse in fortunes when they host Exeter on October 5.
Despite lamenting individual mistakes, Newcastle director of rugby Dean Richards tried to remain upbeat and he said: "We lost the game because we made too many individual errors and it cost us dear.
"Last season our aim was to avoid relegation, which we did, but we scored only one try in our first five or six games. This season we are scoring tries which is a good thing."
The visitors made a decent start to the contest with Wasps as Juan Pablo Socino's kick gave them the lead inside two minutes.
But Varndell responded shortly after by crossing over, which helped the home side establish a 17-11 lead at the break.
Wasps then asserted their dominance after the break on their way to a win that moved them up to fifth in the Aviva Premiership table.
Change in fortunes
Elsewhere Exeter ended their own drought as they won their first home match at Sandy Park since March with a comfortable 36-13 victory over Harlequins.
Tries from Thomas Waldrom, Henry Slade and Jack Yeandle coupled with excellent kicking from Gareth Steenson saw the Chiefs cruise to a much-needed win.
Exeter head coach Rob Baxter said: "It was a big reward for the players and the hard work that they have been putting in.
"We haven't always felt that we have got the reward for the hard work at home when we have lost some of these close games."