Manchester United midfielder Ander Herrera is facing another spell on the sidelines after suffering a fractured rib against West Ham on Saturday.
The 25-year-old was substituted in the 74th minute, and looked in some discomfort. His injury leaves Van Gaal short in the middle of the park, and it could see a return to the starting XI for Darren Fletcher.
This isn't his first injury of the season, with Herrera having been out for three games at the start of the season with an ankle complaint.
Herrera used social media to announce the blow, vowing to remain positive despite of his blow.
"A real shame this injury, but now's not the time to feel sorry for myself. I'm already working to be back as soon as possible!" said Herrera on Twitter.
Herrera's injury only adds to the headache already being suffered by United boss Louis Van Gaal. He joins Wayne Rooney, banned after his red card on Saturday, Ashley Young, Michael Carrick, Marouane Fellaini, Jesse Lingard and Phil Jones who are all out injured.
All look set to miss Sunday's tie against Everton, yet with a two week international break to recover, it could be a possibility to see Phil Jones and Michael Carrick back for the trip to West Bromwich Albion.
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