As reported by the Daily Express, the managerial trio of Louis van Gaal, Jose Mourinho and Brendan Rodgers are all desperate to land the £20 million-rated Slovakia international who who has spent seven years at the Stadio San Paolo.
Hamsik - who joined Napoli from Serie B outfit Brescia in 2007 - is obviously a very influential figure at the club and, as such, appears to be free to decide his own future.
"Marek can be sold whenever he wants, but as long as he is comfortable in Naples he doesn't take anything else into consideration," agent Juraj Venglos said.
However, despite his client evidently holding a great position of power with regards to his individual fate, Venglos suggested that Hamsik was currently content to remain with Napoli despite an underwhelming start to the 2014/15 campaign that has seen question marks emerge over the future of manager Rafael Benitez.
"If we decided that he wants to be sold then we would say so, but Marek is currently doing well with Napoli," he added.
Indeed, the 27-year-old - renowned for his habit of sporting rather interesting and daring hairstyles - has made four appearances so far this term but surely cannot be content with Napoli's current position in the Serie A standings.
This is certainly not the first time that Manchester United have been mentioned iwith regard to a potential swoop for the Slovak captain, although it is questionable whether he is quite what the club require at present with Louis van Gaal notably short of numbers in defence and also having acquired the services of Angel di Maria in a British record transfer deal back in August.
Liverpool and Chelsea could be more realistic destinations in the event that Hamsik does decide he needs a fresh start away from Italian football, although again the latter are not exactly desperate to make additions to what is already a formidably strong first-team squad at Stamford Bridge.