Hull City will travel to Liverpool with their hands full of injury worries. With two goalkeepers and several outfield players injured, Steve Bruce will have to make several adjustments to his side.
Liverpool on the other hand will be tired from their midweek Champions League fixture against Real Madrid in which they were exhausted.
Brendan Rodgers will have the mind boggling decision whether to start goal starving forward Mario Balotelli. The Italian has only managed to score one goal for the Reds since joining in the summer. Daniel Sturridge, Mamadou Sakho and Jon Flanagan will have to watch from the sidelines with injuries.
Allan McGregor and Steve Harper are both struggling with injuries so in steps Eldin Jakupovic who came on to replace Harper at half time in Hull's 2-2 draw with Arsenal. That also means that Rory Watson will be taken as a substitute, who if in the unlikely event Jakupovic picks up an injury will make his Premier League debut.
Injuries haven't been Hull's best friend of late, losing Robert Snodgrass on the season opener. They then lost Michael Dawson and in form striker Nikica Jelavic last week who will face at least six weeks out.
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During the week, Steve Bruce also confirmed that key player Andy Robertson and Tom Huddlestone although the pair are likely to start. In a press conference on Thursday, Huddlestone said "it's feeling much better this week than it was last week and I still lasted the full 90 against Arsenal so I'm fairly confident".
When this fixture is announced, who can forget last season's thrilling tie between the two sides which saw the Tigers maul Liverpool 3-1 in front of a pleased and most definitely shocked home crowd. But times have changed now for the Reds.
Hull City may fancy their chances
With no Luis Suarez and a slightly more dull form of results, Hull may fancy their chances especially with their mouth watering away record this season. Having only lost one of their away fixtures so far, they will travel to Anfield brimming with confidence after a surprising and hard-earned point at the Emirates last week.
Whereas Liverpool had to salvage a dramatic victory at Loftus Road on Sunday, aided by two avoidable own goals. Brendan Rodgers' side have only just got back on the rails after a torrid September.