Federico Fazio is suspended for Tottenham Hotspur's Premier League match against Newcastle United on Sunday at White Hart Lane.
The summer signing for Sevilla made his first league start for Spurs last week against Manchester City, but was sent off for fouling Sergio Aguero as the Lilywhites gave away three penalties in the 4-1 defeat to the league champions.
Joining the centre back on the sidelines are Nabil Bentaleb with an ankle injury, Kyle Naughton (ankle), who is still feeling the effects of Ryan Bertrand's challenge from the win over Southampton, and Kyle Walker, who continues to recover from lower abdominal surgery from the summer.
Spurs will be looking for revenge after a Tim Krul-inspired 1-0 win for Newcastle in the corresponding fixture last season. Loic Remy scored the only goal of the game for Alan Pardew's side in November 2013.
During the 5-1 win over Asteras Tripolis in the Europa League on Thursday Spurs showed a rarely seen ruthlessness in front of goal.
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Harry Kane's hat-trick will put pressure on Mauricio Pochettino to give him his first league start of the season, while if Erik Lamela can transfer his continental form into the league the home crowd will be hoping Tottenham can get back to winning ways domestically.
Goalkeeper Hugo Lloris is not suspended, despite picking up a red card in the midweek victory, and Tottenham Hotspur fans will be expecting another win against the Toon after winning four of the last five when the Magpies have arrived at White Hart Lane.