Louis van Gaal faces José Mourinho, his former prodigy, as his new Manchester United side face their biggest challenge yet. League leaders Chelsea go into the clash three points clear at the summit and five points clear of Manchester City, who are widely considered as their only primary competitor in the title race, all with a game in hand.
Both sides have been riddled with injuries and absentees over the past few days, with Radamel Falcao ruled out of the fixture. Manchester United's Ángel dí María suffered a muscular strain at The Hawthornes on Monday night, but intensive treatment means that the Argentine playmaker should be available for selection.
Michael Carrick is hoping to return to the centre of midfield, following an appearance for United's under-21s. Wayne Rooney remains suspended following his sending off against West Ham, with this the last fixture United's skipper is due to miss.
In Mourinho's court, a stomach virus combined with a niggling hamstring injury saw Spanish talisman Diego Costa effectively ruled out, only for him to be brought back into contention. Fellow forward Loïc Rémy has, however, been certainly ruled out due to a groin injury sustained whilst scoring against Maribor in midweek. André Schürrle has also returned from illness to compete with Willian for his space in Mourinho's side. Full-back Azpilicueta is suspended followingMichaelcard delivered last weekend.
Courtois; Ivanović, Cahill, Terry, Luís; Matić, Fàbregas; Willian, Oscar, Hazard; Costa
De Gea; Rafael, Jones, Rojo, Shaw; Blind, Herrera, Mata, dí María, Januzaj; van Persie