Mauricio Pochettino welcomes back rested quartet Younes Kaboul, Aaron Lennon, Kyle Naughton and Emmanuel Adebayor for Tottenham's match against Stoke at White Hart Lane.
The four players were left in London as Spurs travelled to Greece to face Asteras Tripolis in the Europa League.
Goals from Harry Kane and Andros Townsend helped Pochettino's side to a nervy 2-1 win on Thursday night, and the English duo will be pushing for a starting spot on Sunday.
Kane scored his tenth goal of the season with his header against the Greeks and with Adebayor and Roberto Soldado struggling in front of goal, many might think the England U21 striker would lead the line against Mark Hughes' side.
However, Stoke's physicality and aerial threat will see Adebayor return to the side although this may be the Togolese forward's last chance to impress for a while.
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Despite this, Kane could get his chance in place of Christian Eriksen. The Dane has struggled to replicate last season's form and Pochettino may go with a more physical approach.
In defence, Naughton should return for Eric Dier while Hugo Lloris will come back into the side for Michel Vorm, along with the usual league regulars.
The only long term absentees are Kyle Walker (abdomin) and Nabil Bentaleb (ankle)
Predicted starting XI:
Lloris; Naughton, Vertonghen, Kaboul, Rose; Capoue, Mason; Lamela, Chadli, Kane; Adebayor
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