Arsenal have their best chance to beat Manchester United for the first time since 2011 when the depleted Red Devils arrive in north London on Saturday.
Louis van Gaal has an injury crisis to rival the very worst of Arsene Wenger's, of which there have been many since he first took charge of Arsenal in 1996.
All-in-all, Manchester United could be without 12 first team stars on Saturday including five defenders and record signing Angel di Maria. Radamel Falcao could make it back, but he hasn't played any part in Manchester United's last three games and barely looked fit in those.
So we are approaching a rare turn of events which sees Arsenal as clear favourites to beat their Premier League rivals. Once a title clash, we now see the fallen giants scrapping it out for the also-ran places.
However, there is no love lost in this clash and Arsenal fans will be fully expecting their Gunners team to come out blazing to take advantage of their rival's injury troubles. Having seen their team go down 2-1 against Swansea City before the international break, Arsenal are expected to win.
But although the international break has served as a welcome distraction from Arsenal's shock defeat, he can not use that as an excuse to not make changes. In fact the Frenchman needs to make as many as three big calls to make sure the Gunners are up to scratch.
The team against Swansea City suffered from a chronic lack of discipline. Although they dominated the game at 1-0 up, they invited Swansea back into the game. It wasn't the entire team's fault. Individual performances let that game slip and they need to be punished.
Obviously Nacho Monreal is the first candidate for the chop. He is not capable of playing a centre-back and failed to control Bafetimbi Gomis. How will he do against the likes of Robin van Persie and Wayne Rooney? Not well, is our guess. Giving Hector Bellerin a chance at right-back will allow Calum Chambers to move into a centre-back role where he thoroughly impressed earlier this season impressed.
Mathieu Flamini is likely to make way for the returning Mikel Arteta while the poor form of Aaron Ramsey should see him dropped in favour of Jack Wilshere, fresh from two man of the match performances for England.
Arsenal predicted XI
Szczesny, Bellerin, Mertesacker, Chambers, Gibbs, Arteta, Wilshere, Cazorla, Sanchez, Oxlade-Chamberlain, Welbeck