Dmitri Bulykin made the most of a rare start to score the only goal of the game but it was nowhere near enough to overturn Zenit´s 4-1 advantage from the first leg.
Leverkusen knew they had a mountain to climb after last week´s demolition and began the game brightly. Bulykin broke through the Zenit defence after just four minutes but Viacheslav Malafeev saved well at his feet.
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