The Anfield club head to Old Trafford off the back of a 3-0 embarrassment at home to West Ham United, and Clyne has urged the Reds to 'be at Manchester United's throats' on Saturday.
The Red Devils also lost their last game, a 2-1 defeat to Swansea City, which means the match is vital for both teams, not just for bragging rights, but for early points in the Premier League.
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Clashes between the two great rivals are always feisty, and the former-Southampton defender has claimed his new team will have to be at it from the off, if they want to take anything away from the 'Theatre of Dreams.'
Speaking to the club's official website, the 24-year-old said: "One of the reasons I signed for Liverpool is to play in big matches like this. Working hard, playing on the front foot and taking the game to them is going to be key.
"We can't allow them to pass the ball around as they like to or have too much free space.
"We need to be at their throats from the start, not let them settle in the game, and with the quality we have up front we can cause them problems."
The England international has made an impressive start to his career at Anfield, slotting in to the right-back position with ease.
However, the home defeat to the Hammers threw up some major concerns for the Reds, and Brendan Rodgers' men will need to make a vast improvement defensively, if they want to take anything away from Old Trafford.
Louis van Gaal's Manchester United have failed to set the world alight so far this season, but it is a given that his players will up their game when Liverpool come to town.
Regardless of either teams recent form, one thing is for sure, we are in for a feisty encounter when these two greats of English football come head-to-head.