Wayne Rooney will miss Manchester United's Champions League clash with PSV Eindhoven as he struggles with a hamstring injury.
The United captain missed the 3-1 win against Liverpool with the same problem and has failed to recover in time for the trip to Holland. The 29-year-old is preparing for a return in the Red Devils' next league game - a trip to Southampton - according to the club's official website.
Youngsters James Wilson and Andreas Pereira will join up with the 18-man squad that disposed of Liverpool at Old Trafford.
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Despite the England captain's poor form this season, his presence in the dressing room and leadership on the pitch will be missed by United.
Europe's elite competition offered Rooney a welcome break from the Premier League, as he scored a hat-trick in the 4-0 demolition of Club Brugge, in the play-off round.
In the absence of Rooney, Marouane Fellaini failed to impress as the lone striker and struggled to get involved in the game. However, Anthony Martial is in line for his first United start in the group-stage opener.
After a dream start to his Old Trafford career, Martial will be hoping to stake his claim for a starting spot at Southampton with an impressive performance at the Philips Stadion.
The game will also see Memphis Depay return to his former stomping ground and the Dutch international will be hoping for a marked improvement after being substituted at half-time against Liverpool.
The introduction of Ashley Young changed the dynamics of the game after a drab opening half, and it would come as no surprise to see the English winger replace Memphis in the starting 11.
Will Manchester United get the better of PSV Eindhoven? Have your say below!