Fresh from the international break, Real Madrid will be looking to kick on from their 5-0 hammering of Real Betis.
Granada are always a willing opponent and shipped nine goals the last time they were at the Santiago Bernabeu.
Rafa Benitez won't care if one goal wins it this time as long as his staff accede to his particular way of playing.
Los Blancos will have to do it without two of their first XI who have succumbed to injuries whilst on duty with their countries.
Let's take a look at three things that could affect the outcome of this one...
Real have been dealt an injury blow which could affect the way in which the team set up, if not the overall result.
James Rodriguez has been ruled out for a month whilst right-back Danilo won't return until early October.
Both are shoo-ins for their respective positions when fit and although Isco and Dani Carvajal are fine replacements to have on hand, there might not be quite the same zip about Madrid's game. At least not in the early stages.
It's also the second year in a row that James has suffered with similar injuries and this could be something for the medical staff at the club to run the rule over whilst the player finds himself on the sidelines.
Lift-off for Ronaldo
Finally, Cristiano Ronaldo will have something to shout about at the conclusion of proceedings.
A scorer of just the five the last time the teams met, the likelihood of at least a brace for the Portuguese is high.
Since starting in Madrid in 2009, there's barely a weekend that goes by when Ronaldo doesn't add his name to the score sheet.
If he weren't to trouble it for a third match week in a row, statisticians will need to scour the record books to see if it's ever happened before!
If Real think that this match is going to be another cakewalk, then they could come unstuck.
Jose Ramon Sandoval has a reasonable group of players, who all share one thing in common.
Unquestionable team spirit and desire.
That is a pre-requisite of every side of course, but rarely are a group so together this early in the season.
Real won't need reminding of their opening day draw at Sporting Gijon, a team with similar values and aspects to their play.
In Youssef El-Arabi, Granada possess a striker or genuine quality and if Success or Ruben Rochina can continue to supply the bullets, El-Arabi will have no problem in firing them.
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