The four-time Ballon d’Or winner has scored more goals in the Clasico (21) than any other player in the fixture’s history and he’ll be desperate to feature at the Bernabeu this weekend following his lengthy spell on the sidelines.
Barça fans - as well as neutrals - will be desperately hoping to see Messi back in action for the first time since September, and when you scroll down this page and see the videos we’ve found today, you’ll understand why.
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The Argentina international has produced some of his most memorable performances against Los Blancos, whose legendary former goalkeeper Iker Casillas must be mightily relieved that he doesn’t need to suffer more humiliation at the hands of Messi in this fixture after signing for FC Porto in the summer.
Messi is already the overwhelming favourite to win a record-breaking fifth Ballon d’Or award in January - even Cristiano Ronaldo has conceded defeat on that front - and an impressive cameo performance in this weekend’s fixture, presuming he doesn’t make the starting line-up, should seal it for the world’s most talented footballer.
9 times Lionel Messi destroyed Real Madrid
Here are eight moments when Real Madrid have had no answer to Lionel Messi’s genius.
Making Roberto Carlos fall over
Destroying Fabio Cannavaro and Roberto Carlos
Making Fabio Cannavaro crash into the post
Hat-trick v Real Madrid aged 19
This assist for Andres Iniesta
This assist for David Villa
Knocking Real Madrid out of the Champions League with a wonder goal
This peach of a free-kick past Iker Casillas
And this other perfect free-kick past Iker Casillas
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