Arsenal need to beat Olympiacos by two goals in Greece if they are to qualify for the latter stages of the Champions League. Even with a full strength squad, Arsene Wenger knows it is not going to be easy.
But the task ahead has gone from difficult to formidable after Arsenal's injury nightmare continued to worsen during Sunday's 1-1 draw with Norwich City.
Alexis Sanchez, Santi Cazorla and Laurent Koscielny all sustained injuries and, according to the Telegraph, at least two of them are facing significant time out.
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Sanchez is believed to have torn his hamstring while Cazorla has suspected ligament damage in his knee. Scan results will not be back until tomorrow, but if Arsenal's suspicions are confirmed they will likely miss the rest of 2015.
Wenger has been criticised for not resting Sanchez, who played his 90th match for club and country since joining the Gunners from Barcelona in 2014. The Chilean has appeared in every Premier League and Champions League game so far this season, starting 18 out of 19.
The Frenchman insists Sanchez was fit and ready to face the Canaries despite earlier revealing he had sustained a slight hamstring problem during Tuesday's 3-0 win over Dinamo Zagreb.
Having now injured that hamstring far more seriously, plenty have question Wenger's decision to play him. However, Wenger may have chosen to rest his star player had the injury crisis at the Emirates not already been so bad.
Arsenal's season has taken a turn for the worse with the club garnering just two points from their last three league matches. That poor form has coincided with injuries to Theo Walcott, Alex Oxlade-Chamberlain, Francis Coquelin and Aaron Ramsey.
While Coquelin is out for the long-term, the other three are expected to be available to Wenger for Saturday's game against Sunderland, but their return has been negated by the loss of Cazorla and Sanchez. They could miss as many as seven games over the festive period by which time Arsenal's title hopes could be over.