Francis Coquelin, the Spaniard's midfield partner, has also been sidelined until the new year, which leaves the Gunners with no identified defensive midfielders in the senior squad.
The recurrence of long-term injuries at the Emirates has been consistent in recent years, with the midfield seemingly most fragile.
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Questions are now being asked of the current medical staff and Arsene Wenger, whose stubbornness in the transfer window could once again spurn his side's title challenge.
With the Frenchman failing to spend big on an outfield marquee signing over the summer, frailties in the squad were inevitable.
As a result, injuries to Keiron Gibbs, Alexis Sanchez and Coquelin have left the Gunners with very limited options for rotation.
With the latter not expected to return until early next year and Cazorla now ruled out for a similar time frame, Wales international Aaron Ramsey will likely shift from right wing into a box-to-box midfield role - a position in which he thrived two seasons ago.
Joel Campbell - Costa Rica's World Cup wonderkid - could be set for an extended spell in the starting line-up with Sanchez out for the foreseeable future, though Theo Walcott is nearing a return and Alex Oxlade-Chamberlain announced his own over the weekend with a cameo against Norwich City.
With a Premier League title challenge now looking out of Arsenal's reach, signings will undoubtedly have to be made in January to sure up their defence, midfield and attack, all of which in dire need of greater stability.