Since the Premier League's inception in 1992, the pair have met 22 times in Manchester, with the hosts coming out on top on 13 occasions.
The Gunners have often struggled in this fixture, but recent form suggests momentum is shifting.
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Both sides will be desperate for victory amidst their differing targets. Louis van Gaal's side are currently six points adrift of a Champions League place and will need to be at their very best to thwart the north Londoners.
Arsenal, on the other hand, are two points shy of top-spot and it's widely agreed this season is their best chance to lift the Premier League trophy for the first time in 12 years - and victory on Sunday will heighten that belief.
Here, we take a look back through the archives to remind you of five classics served up in Manchester.
Manchester United 6-1 Arsenal - February 25, 2001
The Red Devils were well on their way to a seventh Premier League crown before the visit of Arsenal in 2001. Sir Alex Ferguson's side commanded a 13 point lead prior to kick-off and they extended that tally with a mesmerising performance to stun their close rivals.
Dwight Yorke opened the scoring after just two minutes before Thierry Henry equalised for his 18th of the season. However, the Gunners were on level terms for just two minutes before Yorke restored United's lead and in the 22nd minute completed his hat-trick to give the hosts a 3-1 cushion.
Things went from bad for worse for Arsenal as Yorke turned provider for Roy Keane who duly dispatched United's fourth, before Nicky Butt capitalised on a Giles Grimandi mistake to tee up Ole Gunnar Solskjaer for number five - all before the half-time whistle.
The second half saw Wenger's side stem the tide somewhat, but Teddy Sheringham showed little mercy on Arsenal as he found the net and condemned Arsenal to what was their heaviest Premier League defeat.
Manchester United 0-1 Arsenal - May 8, 2002
The match itself might not have been a classic, but the result was monumental. Arsenal made the trip up north knowing that a point would be enough to secure the Premier League title after clinching the FA Cup four days prior.
Wenger's men had the unenviable task of striding into enemy territory without the likes of Henry, Tony Adams and Dennis Bergkamp, but Sylvain Wiltord made sure they wasn't missed, the Frenchman scoring the only goal of the game to gift the Gunners their second Premier League success.
Arsenal's victory meant they finished the 2001/02 campaign without a single away defeat to their name - a record they would replicate in 2003/04.
Manchester United 2-0 Arsenal - October 24, 2004
Arsenal were riding the crest of a wave before they locked horns with their fierce rivals in 2004 having gone unbeaten in their previous 49 league games.
However, the north Londoners came crashing back down to earth after Ruud van Nistelrooy and a birthday goal for Wayne Rooney put them to the sword. United went into the match without skipper Roy Keane but his absence done little to hinder the hosts.
Sol Campbell was adjudged to have bought down Rooney inside the box and Van Nistelrooy stepped up to put United infront, erasing the memory of his last-minute spot kick miss against the same opposition a year previous.
Arsenal endeavoured to get back into the game but Rooney made sure their unbeaten run was over after he steered home at the back post. The victory left United eight points behind their visitors, but it was Chelsea who ultimately went on to win the league that season.
Manchester United 0-1 Arsenal - March 14, 1998
If ever there was a single game that turned the title race on it's head, it was this one. Arsenal were languishing nine points behind United knowing they had to dethrone their hosts to have any chance of hauling themselves back into the title race.
In what was a fairly tight and cautious affair, Marc Overmars scored the only goal of the game which gave the Gunners their first Premier League win at Old Trafford.
The Dutch winger showed discipline and composure to slot the ball past the on-rushing Peter Schmeichel with just 11 minutes remaining.
To say the result was pivotal would be an understatement. Wenger's side went on to win their games in hand and subsequently win the league in the Frenchman's first full season.
Manchester United 8-2 Arsenal - August 28, 2011
There's no other result in Premier League history that stands out as much as this one; absolutely no one would have predicted the ruthless onslaught that United handed to their depleted rivals.
Rooney was once again the thorn in Arsenal side's, notching his sixth hat-trick in United colours.
Ashley Young struck two long-rangers whilst Danny Welbeck, Nani and Park Ji-sung also found the back of the net as Wenger looked on in horror, his side powerless to stop the juggernaut of continued home pressure.
Robin van Persie and Theo Walcott scored consolation goals after the former missed a first-half penalty on what was a torrid afternoon for the visitors.
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