Having taken game one in Canada from the Toronto Raptors, the Miami Heat now find themselves 2-1 down in their Eastern Conference semi-finals series.
The series has been hotly contested with every game going down to the wire - game three was the first encounter that did not go to overtime. When a series is so tight, injuries have the possibility to swing it one way or another.
Miami suffered a major blow in the second quarter as Hassan Whiteside experienced a repeat of his game one injury following a tangle under the Toronto basket with teammate Luol Deng.
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The center has a right knee sprain and will be given an MRI scan by Heat doctors on Sunday. Following the game, Dwyane Wade said the injury was part of basketball and it was time for one of his other teammates to step up.
In the post-game press conference, the guard said: "Losing him [Whiteside] within a game was very tough, he's a big part of what we do, so we will find out more tomorrow.
"Whatever happens, guys just have to step up. That's a part of the NBA, injuries are part of the game, it's one of the worst parts of the game but it's a part of it and you have to have guys that are professional enough to stay ready all year.
"Guys just have to step up in a different way, no one can be Hassan Whiteside, so if we without him we got to have confidence in U-D [Haslem], Amar'e [Stoudemire] and Josh [McRoberts] they can do what they do that is totally different from what Hassan does."
The Toronto Raptors have injury concerns of their own after Jonas Valanciunas suffered a right ankle problem during the second half in South Beach.
But Miami's primary concern will be finding a way to play without Whiteside if the MRI scan returns bad news. Josh McRoberts and Udonis Haslem were deployed at different stages throughout the night, but neither player made much of a telling impact on offence. Amar'e Stoudamire only played for four minutes.
Whiteside looked in pretty bad shape as he was helped to the locker-room and Miami may have to prepare for the very real possibility that he could be out for Monday night's game four.