The Last Stylebender will defend his middleweight title against Jared Cannonier early on Sunday morning in the main event of UFC 276 in Las Vegas.
Besides being one of the most popular fighters on the roster, Adesanya, 32, is also an ambassador for online casino Stake.com.
And Drake, who also sponsored by the betting company, gave him a call to wish him good luck ahead of his fight later tonight.
The rapper also revealed that he has placed a whopping $1 million bet on him to retain his title this weekend.
He said: “Bro, I already know what time it is. You know, I put a light million up.”
Adesanya replied: “Light mil?”
Drake added: “A light mill. I had to put a light mil on my brother. Return on investment is a lock.”
WATCH: Rap artist Drake has placed a whopping $1 million bet on Israel Adesanya to beat Jared Cannonier
Check out the video below…
The Canadian music artist continued: “I just want to wish you good luck.
“You know I love you, brother. You’re different. You’re a different guy, bro.
“I have a deep, deep, deep love and respect for you. A deep love and respect.”
Adesanya was touched by his comments, before replying: “You’re giving me chills right now brother I appreciate that as a fellow empath and a rake himself I really appreciate that so you’re the f***ing man.
“Every f***ing time bro you drop on the mic it’s game over so keep doing what you’re doing.
“I’ve been blessed to watch you play twice live in Auckland. It was [inaudible] and then Spark Arena. Eventually you’re going to watch me live soon.”
Drake insisted: “Oh no, for sure that’s a guarantee. I’ve got to say, good luck brother, I’ll hit you up after the fight.”
And now fans have taken to social media to express their concern for Adesanya as they fear he may have fallen victim to the infamous Drake ‘curse’.
“Great now I’m worried,” one fan wrote on Twitter.
“GOD PLEASE… NOT THE DRAKE CURSE…PLEASE. He’s never won a bet in MMA,” another user said in the comments.
“We all know what happens when Drake gets involved,” another concerned individual commented.
While a fourth added: “Bet the house on Jared.”
And a fifth tweeted: “Cannonier wins by 1st round KO.”