Wolves welcomed the reigning Premier League champions to Molineux as the underdogs.
Bruno Lage would have wanted his side to be resolute in defence and frustrate the Citizens.
But it was City who took the lead within a minute. Kevin De Bruyne swung a ball into the box and Jack Grealish converted from close range.
Erling Haaland then doubled his side’s lead 15 minutes later. The unstoppable forward marauded towards goal and fired a right-footed shot from outside the box into the bottom corner.
Wolves had their backs up against the wall and their hopes of getting back in the game were all but extinguished when Collins was sent off for a very high challenge on Grealish.
The defender, who signed for the Wolves in a £20.5 million move from Burnley in the summer, caught Grealish in the abdomen with a flying kick and was shown a straight red card by referee, Anthony Taylor.
Jermaine Jenas was covering the game on BT Sport and was very critical of Collins, calling it a ‘terrible challenge.’
The Irish defender protested but the sending off was never going to be overturned.
VIDEO: Collins sent off for fouling Grealish
¡La patada de Nathan Collins a Javi Grealish!— En el VAR (@EnElVar) September 17, 2022
Faut être un terroriste pour faire ce genre de faute. Nathan Collins mérite bien plus qu’un rouge là-dessus.pic.twitter.com/oW5cCssdi2— Amaury Gonçalves (@AmauryGnclvs) September 17, 2022
Collins continued his protests as he made his way to the dressing room.
BBC reporter Simon Stone was at Molineux and noted: “Nathan Collins made a slow walk to the dressing rooms, shaking his head as he went.
It's gone from bad to worse for Wolves…— Football on BT Sport (@btsportfootball) September 17, 2022
Nathan Collins receives a straight red card for a challenge on Jack Grealish 🟥 pic.twitter.com/iPT7poYdkg
“He stopped to plead his innocence to fourth official Tony Harrington as he made his way off the field, still believing he had done nothing to warrant a red card.”
Grealish needed treatment and was on the floor for some time.
Fortunately he recovered and was able to continue.
He was booed by the Wolves fans for the remainder of the half, who believed Grealish made the most of the tackle.