Spurs were frustrated by Leicester for the majority of the first-half at the King Power Stadium, but Neville found a special way to break the deadlock.
The defender received the ball in the middle of the pitch, and with no Leicester players around her, drove forward.
She then looked up and struck the ball over the head of goalkeeper Kirstie Levell. The astonishing strike sparked jubilant celebrations among her teammates.
Neville’s goal then seemed to inspire Drew Spence, who doubled Tottenham’s lead on the stroke of half-time.
The 29-year-old, who was making her debut for the Lilywhites, found herself with the ball from a free-kick outside the penalty box.
Her low drive towards goal evaded Levell and snuck into the bottom left-hand corner.
It wasn’t a perfect debut for Spence, however, with the former Chelsea star turning the ball into her own net in the 58th minute. But Spurs held on to secure a 2-1 victory.
Video: Watch Ashleigh Neville’s astonishing strike for Spurs
Who is Ashleigh Neville?
Neville is not normally known for her goal scoring abilities. Indeed, the right-back has only been on the scoresheet ten times in 100 appearances for Spurs.
She has been a rock in Tottenham’s defence since 2017, however, making a name for herself last season in particular.
Her performances inspired calls from fans for an England call-up, but Neville is yet to be named in a Lionesses squad.
In the meantime, she will hope to help Tottenham Hotspur to a Champions League place for the first time in the club’s history.
The side finished fifth in the WSL last season, but were 10 points off fourth-placed Manchester United.