With just 15 minutes remaining against Bournemouth on Sunday, it seemed Liverpool were cruising to yet another convincing away victory.
Jurgen Klopp's men were 3-1 up thanks to goals from Sadio Mane, Divock Origi and Emre Can, with the hosts seemingly dead and buried.
But then, disaster. Substitute Ryan Fraser scored in the 76th minute to give Bournemouth hope of an unlikely comeback before Steve Cook struck two minutes later.
From Fraser's cross, the captain controlled the ball inside the 18-yard box and fired into the bottom-left corner to send Dean Court into raptures.
Bournemouth then pushed for a winner and they duly delivered, Nathan Ake pouncing on a goalkeeping error to tap home and seal an historic win.
Defeat for Liverpool meant they were unable to close the gap on Chelsea, who top the Premier League on 34 points following their 3-1 victory over Manchester City.
The Reds remain in the title race but now sit third, behind second-placed Arsenal.
However, for club legend Jamie Carragher, Liverpool cannot win the Premier League this season with one player in their side: Lucas Leiva.
He said: "Panic seems to set in. Liverpool seem to go through this a lot. The goalkeeper there has got to do an awful lot more (for the fourth goal) but it comes from players not making the right decision.
"People keep talking about Liverpool's defensive problems. The back four, maybe Lucas as your third-choice centre-back, it is probably not enough if you want to go and win the title.
"But I don't think Liverpool have got a poor defence or are poor defensively."
Carragher also criticised goalkeeper Karius, who was arguably at fault for two of Bournemouth's goals.
"We were critical of Karius after the game," he added. "If you've got a poor defence your keeper is getting worked, but he's not making many saves, that tells me Liverpool haven't got a poor defence. The goalkeeper is not having to do anything.
"The reason I was critical of him yesterday is that you can't expect your team to press for 90 minutes, there will be games when people make mistakes.
"And there was two games where he got asked questions. One was Swansea, and he struggled, and he was lucky that day.
"He didn't get the luck (against Bournemouth). That's why we were critical, because he got asked questions and he never answered them.
"But it's still early days for his Liverpool career, I'm not saying he's finished by any stretch of the imagination but over the next 12-18 months that has got to improve."